Thesis-2013-Patel.pdf (5.42 MB)
Discovery of stress biomarkers in biological matrices using novel sample collection techniques Inorganic and Organic Mass Spectrometry
thesis
posted on 2014-06-12, 08:19 authored by Pareen PatelNew methodologies for the collection and analysis of biological samples from psychological,
physical and emotional stress are described. Currently, there is little research relating to the
elemental, VOC and small molecule changes in biological samples as a consequence of stress
on the human body, with much of the current research indicating physical symptoms.
This research sought to measure chemical changes in three different categories of stress.
The first uses an existing PASAT intervention to induce psychological stress and a further two
new methodologies using exercise to induce physical stress and a trapped human in a
simulation of a collapsed building to induce emotion stress. Psychological, physical and
emotional stress elemental profiles are compared against their respective chemical baseline
profiles. Skin samples are collected from the foreheads of participants who endured
emotional stress while drool saliva, urine, plasma and forehead skin samples were obtained
from physically stressed participants. Furthermore, drool saliva is also obtained from the
individual who experienced emotional stress. [Continues.]
Funding
Research School of Health and Life Sciences.
History
School
- Science
Department
- Chemistry
Publisher
© Pareen PatelPublication date
2013Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.Language
- en