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Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men
journal contribution
posted on 2014-07-09, 10:55 authored by Stuart R. Gray, M. Robinson, Myra A. NimmoThe pleiotropic cytokine interleukin-6 (IL-6) has
been demonstrated to increase during exercise. Little is
known regarding the response of the soluble IL-6 receptors
(sIL-6R and sgp130) during such exercise. The aim of the
current study was to investigate the response of plasma IL-
6, sIL-6R and sgp130 during fatiguing submaximal
exercise in humans. Twelve participants underwent an
incremental exercise test to exhaustion and one week later
performed a submaximal exercise bout (96±6% lactate
threshold) to volitional exhaustion. Blood samples taken at
rest and immediately post exercise were analyzed for IL-6,
sIL-6R and sgp130. IL-6 increased (P<0.01) by 8.4±8.9 pg
ml−1 (75.7%) during the exercise period. sIL-6R and sgp130
also increased (P<0.05) by 2.7±3.9 ng ml−1 (9.6%) and
37.7±55.6 ng ml−1 (9.6%), respectively. The current study is
the first investigation to demonstrate that alongside IL-6,
acute exercise stress results in an increase in both sIL-6R and
sgp130.
History
School
- Sport, Exercise and Health Sciences
Published in
CELL STRESS & CHAPERONESVolume
13Issue
2Pages
247 - 251 (5)Citation
GRAY, S.R., ROBINSON, M. and NIMMO, M.A., 2008. Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. Cell Stress and Chaperones, 13 (2), pp. 247 - 251.Publisher
Springer © Cell Stress Society InternationalVersion
- VoR (Version of Record)
Publication date
2008Notes
Closed access.ISSN
1355-8145Publisher version
Language
- en