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Proteolysis, caloric restriction and aging
journal contribution
posted on 2015-03-06, 13:48 authored by K. Merker, Alexandra StolzingAlexandra Stolzing, Tilman GruneThe nature of the aging process has been the subject of considerable speculation. It is believed that free radical damage to cellular components is one of the main contributors to the aging process. Studies on proteins have shown age-related decline in enzyme activities, age-related accumulation of oxidized proteins and a decline of the proteolytic machinery of the cell. The proteasome, a highly regulated intracellular proteolytic system, is the major enzymatic system responsible for the degradation of damaged proteins. The current knowledge on regulation and of the properties of this unique proteolytic system with special emphasis to the aging process are discussed in this review. Since it is known that caloric restriction (CR) is the only method to delay the aging process and extend the maximal lifespan the effects of CR on the age-related decline in protein degradation is highlighted. © 2001 Published by Elsevier Science Ireland Ltd.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Mechanisms of Ageing and DevelopmentVolume
122Issue
7Pages
595 - 615Citation
MERKER, K., STOLZING, A. and GRUNE, T., 2001. Proteolysis, caloric restriction and aging. Mechanisms of Ageing and Development, 122 (7), pp. 595 - 615.Publisher
© Elsevier Science Ireland Ltd.Version
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2001Notes
This article is closed access.ISSN
0047-6374Publisher version
Language
- en