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Al(OH)(3) facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

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posted on 2015-06-22, 13:11 authored by X. Cui, M.A. Green, P.J. Blower, Diwei ZhouDiwei Zhou, Y. Yan, W. Zhang, K. Djanashvili, D. Mathe, D.S. Veres, K. Szigeti
Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)3-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with 18F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with 64Cu.

Funding

This research was supported by the Centre of Excellence in Medical Engineering Centre funded by the Wellcome Trust and EPSRC [grant number WT088641/Z/09/Z], and the Kings College London and UCL Comprehensive Cancer Imaging Centre funded by the CRUK and EPSRC in association with the MRC and DoH (England), and by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.

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School

  • Science

Department

  • Mathematical Sciences

Published in

CHEMICAL COMMUNICATIONS

Volume

51

Issue

45

Pages

9332 - 9335 (4)

Citation

CUI, X. ... et al, 2015. Al(OH)(3) facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles. Chemical Communications, 51 (45), pp. 9332 - 9335.

Publisher

Royal Society of Chemistry

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  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

Publication date

2015

Notes

This is an Open Access article published by the Royal Society of Chemistry and licensed under the terms of the Creative Commons Attribution Licence http://creativecommons.org/licenses/by/3.0/ which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI

ISSN

1359-7345

Publisher version

Language

  • en

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    untaggedMathematical Sciences not elsewhere classified

    Licence

    CC BY 3.0

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