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Ratiometric detection of adenosine triphosphate (ATP) in water and real-time monitoring of apyrase activity with a tripodal zinc complex
Two tripodal fluorescent probes Zn⋅L1,2 have been synthesised, and their anion-binding capabilities were examined by using fluorescence spectroscopy. Probe Zn⋅L1 allows the selective and ratiometric detection of adenosine triphosphate (ATP) at physiological pH, even in the presence of several competing anions, such as ADP, phosphate and bicarbonate. The probe was applied to the real-time monitoring of the apyrase-catalysed hydrolysis of ATP, in a medium that mimics an extracellular fluid.
Funding
S.J.B. wishes to thank the Ramsay Memorial Fellowship Trust and Durham University for support and funding.
History
School
- Science
Department
- Chemistry
Published in
CHEMISTRY-A EUROPEAN JOURNALVolume
20Issue
48Pages
15768 - 15774 (7)Citation
BUTLER, S.J., 2014. Ratiometric detection of adenosine triphosphate (ATP) in water and real-time monitoring of apyrase activity with a tripodal zinc complex. Chemistry - A European Journal, 20 (48), pp. 15768 - 15774.Publisher
© Wiley-VCH Verlag GmbH & Co.Version
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2014Notes
This article is closed access.ISSN
0947-6539Publisher version
Language
- en