Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study

Background—Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between physical activity and inflammation has been demonstrated, but no long-term prospective data are available. We therefore examined the association between physical activity and inflammatory markers over a 10-year follow-up period. Methods and Results—Participants were 4289 men and women (mean age, 49.2 years) from the Whitehall II cohort study. Self-reported physical activity and inflammatory markers (serum high-sensitivity C-reactive protein and interleukin-6) were measured at baseline (1991) and follow-up (2002). Forty-nine percent of the participants adhered to standard physical activity recommendations for cardiovascular health (2.5 h/wk moderate to vigorous physical activity) across all assessments. Physically active participants at baseline had lower C-reactive protein and interleukin-6 levels, and this difference remained stable over time. Compared with participants who rarely adhered to physical activity guidelines over the 10-year follow-up, the high-adherence group displayed lower loge C-reactive protein ( 0.07; 95% confidence interval, 0.12 to 0.02) and loge interleukin-6 ( 0.07; 95% confidence interval, 0.10 to 0.03) at follow-up after adjustment for a range of covariates. Compared with participants who remained stable, those who reported an increase in physical activity of at least 2.5 h/wk displayed lower loge C-reactive protein ( coefficient 0.05; 95% confidence interval, 0.10 to 0.001) and loge interleukin-6 ( coefficient 0.06; 95% confidence interval, 0.09 to 0.03) at follow-up. Conclusions—Regular physical activity is associated with lower markers of inflammation over 10 years of follow-up and thus may be important in preventing the proinflammatory state seen with aging.