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Label-free electronic detection of interleukin-6 using horizontally aligned carbon nanotubes

journal contribution
posted on 2015-12-17, 13:33 authored by Hu Chen, Teck Kian Choo, Jingfeng Huang, Yi Wang, Yuanjun Liu, Mark PlattMark Platt, Alagappan Palaniappan, Bo Liedberg, Alfred I.Y. Tok
A facile, sensitive, and label-free assay for detection of interleukin-6 (IL-6) using liquid-gated field-effect transistor (FET) sensors based on horizontally aligned single-walled carbon nanotubes (SWCNT) is proposed. This approach relies on the drain current (Id) responses of the transistor upon interactions of IL-6 with its corresponding antibody (IL-6R) immobilized on SWCNT. The proposed immunosensor exhibits superior sensitivity (limit-of-detection = 1.37 pg/mL) in virtue of the reduced tube-to-tube contact resistance, good selectivity (no responses to bovine serum albumin and cysteine were observed and detection of target molecules in serum was achieved) as a result of the highly specific interaction between IL-6 and IL-6R, and excellent stability (no significant degradation in the electronic performance after storage under ambient conditions for up to 3 months) in virtue of the strong adhesion of CNT to the quartz substrate and good horizontal alignment of these tubes. Therefore, the proposed immunosensor is a promising platform for early diagnosis of various diseases (including some cancers) that can be indicated by the circulating level of IL-6.

Funding

This research was funded by the Institute for Sports Research, Nanyang Technological University.

History

School

  • Science

Department

  • Chemistry

Published in

Materials & Design

Citation

CHEN, H. ... et al, 2015. Label-free electronic detection of interleukin-6 using horizontally aligned carbon nanotubes. Materials & Design, 90, pp. 852-857.

Publisher

© Elsevier

Version

  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

This paper is closed access.

ISSN

0264-1275

Language

  • en