AHD manuscript Kidney and Blood Pressure Research.pdf (3.2 MB)
The impact of exercising during haemodialysis on blood pressure, markers of cardiac injury and systemic inflammation - preliminary results of a pilot study
journal contribution
posted on 2016-04-08, 09:04 authored by Maurice Dungey, Nicolette BishopNicolette Bishop, Hannah M.L. Young, James O. Burton, Alice C. SmithBackground/Aims: Patients requiring haemodialysis have cardiovascular and immune
dysfunction. Little is known about the acute effects of exercise during haemodialysis. Exercise
has numerous health benefits but in other populations has a profound impact upon blood
pressure, inflammation and immune function; therefore having the potential to exacerbate
cardiovascular and immune dysfunction in this vulnerable population. Methods: Fifteen
patients took part in a randomised-crossover study investigating the effect of a 30-min
bout of exercise during haemodialysis compared to resting haemodialysis. We assessed
blood pressure, plasma markers of cardiac injury and systemic inflammation and neutrophil
degranulation. Results: Exercise increased blood pressure immediately post-exercise; however,
1 hour after exercise blood pressure was lower than resting levels (106±22 vs. 117±25 mm
Hg). No differences in h-FABP, cTnI, myoglobin or CKMB were observed between trial arms.
Exercise did not alter circulating concentrations of IL-6, TNF-α or IL-1ra nor clearly suppress
neutrophil function. Conclusions: This study demonstrates fluctuations in blood pressure
during haemodialysis in response to exercise. However, since the fall in blood pressure
occurred without evidence of cardiac injury, we regard it as a normal response to exercise
superimposed onto the haemodynamic response to haemodialysis. Importantly, exercise did
not exacerbate systemic inflammation or immune dysfunction; intradialytic exercise was well
tolerated.
Funding
This work was supported by the National Institute for Health Research (NIHR) Diet, Lifestyle & Physical Activity Biomedical Research Unit based at University Hospitals of Leicester and Loughborough University.
History
School
- Sport, Exercise and Health Sciences
Published in
KIDNEY & BLOOD PRESSURE RESEARCHVolume
40Issue
6Pages
593 - 604 (12)Citation
DUNGEY, M. ... et al., 2015. The impact of exercising during haemodialysis on blood pressure, markers of cardiac injury and systemic inflammation - preliminary results of a pilot study. Kidney and Blood Pressure Research, 40 (6), pp. 593 - 604.Publisher
© The Author(s) Published by S. Karger AG, BaselVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2015-10-22Publication date
2015Notes
This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.ISSN
1420-4096Publisher version
Language
- en