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Complex character analysis of heart rate variability following brain asphyxia

journal contribution
posted on 2016-08-08, 08:28 authored by Yuanyuan Cai, Yihong Qiu, Lan Wei, Wei Zhang, Sijung HuSijung Hu, Peter R. Smith, Vincent P. Crabtree, Shanbao Tong, Nitish V. Thakor, Yisheng Zhu
In the present study Renyi entropy and L–Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n = 5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n = 5) without medication. Renyi entropy and L–Z complexity of the R–R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.

Funding

This research is supported by the grant 60272326 of National Natural Science Foundation of China and the 973 grant 2005CB7243 of National Natural Science Foundation of China.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Medical Engineering & Physics

Volume

28

Issue

(4)

Pages

. 297 - 303

Citation

CAI, Y. ... et al., 2006. Complex character analysis of heart rate variability following brain asphyxia. Medical Engineering and Physics, 28 (4), pp.297-303.

Publisher

© Elsevier

Version

  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2006

Notes

Closed access.

ISSN

1350-4533

Language

  • en

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