Final version of manuscript as accepted.pdf (743.83 kB)
Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems
journal contribution
posted on 2017-05-25, 14:06 authored by M. Mijajlovic, D. Wright, Vladimir Zivkovic, J.X. Bi, Mark BiggsLipid vesicles have received significant attention in areas ranging from pharmaceutical and biomedical engineering to novel materials and nanotechnology. Microfluidic-based synthesis of liposomes offers a number of advantages over the more traditional synthesis methods such as extrusion and sonication. One such microfluidic approach is microfluidic hydrodynamic focusing (MHF), which has been used to synthesize nanoparticles and vesicles of various lipids. We show here that this method can be utilized in synthesis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles with controllable size. Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nano-containers with higher biologic compatibility for pharmaceutical and medical applications. © 2012 Elsevier B.V.
History
School
- Science
Department
- Chemistry
Published in
Colloids and Surfaces B: BiointerfacesVolume
104Pages
276 - 281Citation
MIJAJLOVIC, M., 2013. Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems. Colloids and Surfaces B: Biointerfaces, 104, pp. 276-281.Publisher
© ElsevierVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2013Notes
This paper was accepted for publication in the journal Colloids and Surfaces B: Biointerfaces and the definitive published version is available at http://dx.doi.org/10.1016/j.colsurfb.2012.12.020ISSN
0927-7765eISSN
1873-4367Publisher version
Language
- en