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Corrosion of magnesium and magnesium–calcium alloy in biologically-simulated environment

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journal contribution
posted on 2017-09-26, 09:26 authored by Richard Harrison, Diana Maradze, Simon Lyons, Yufeng Zheng, Yang LiuYang Liu
A study of biocompatibility and corrosion of both metallic magnesium (Mg) and a magnesium alloy containing 1% calcium (Mg-Ca) were investigated in in vitro culture conditions with and without the presence of bone marrow derived human mesenchymal stem cells (hMSCs). Chemical analysis of the degraded samples was performed using XRD and FEGSEM. The results from the XRD analysis strongly suggested that crystalline phase of magnesium carbonate was present on the surface of both the Mg and Mg-Ca samples. Flame absorption spectrometry was used to analyse the release of magnesium and calcium ions into the cell culture medium. Magnesium concentration was kept consistently at a level ranging from 40 to 80. mM for both Mg and Mg-Ca samples. No cell growth was observed when in direct contact with the metals apart from a few cells observed at the bottom of culture plate containing Mg-Ca alloy. In general, in vitro study of corrosion of Mg-Ca in a biologically-simulated environment using cell culture medium with the presence of hMSCs demonstrated close resemblances to in vivo corrosion. Although in vitro corrosion of Mg-Ca revealed slow corrosion rate and no immediate cytotoxicity effects to hMSCs, its corrosion rate was still too high to achieve normal stem cell growth when cells and alloys were cultured in vitro in direct contact.

Funding

Funding for this research was provided by the Engineering and Physical Sciences Research Council (Grant no.EPF500491/1) Doctoral Training Centre (R.H. and D.M.) and EPSRC vocational bursary (S.L.).

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Progress in Natural Science: Materials International

Volume

24

Issue

5

Pages

539 - 546

Citation

HARRISON, R. ... et al., 2014. Corrosion of magnesium and magnesium–calcium alloy in biologically-simulated environment. Progress in Natural Science: Materials International, 24 (5), pp.539-546.

Publisher

Elsevier (© Chinese Materials Research Society)

Version

  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 International (CC BY-NC-ND 3.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/3.0/.

Publication date

2014

ISSN

1002-0071

Language

  • en

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