Thesis-1988-Adebayo.pdf (7.48 MB)
Synthetic and antimicrobial studies of nitroimidazole analogues
thesis
posted on 2018-02-26, 14:34 authored by Adelaide T.O.M. AdebayoNew 2-, 4- and 5-nitroimidazole analogues were synthesised using the following methods: (i) SRN1 free radical reaction between nitroimidazole anion and halonitro substrates; (ii) oxidative addition of the anion of 2-nitropropane to nitroimidazole anions. N-1-alkyl derivatives of imidazole, benzimidazole, 5-nitrobenzimidazole, 5- and 6-nitroindazole were similarly prepared. These compounds showed antimicrobial activity;
anaerobes were more sensitive than aerobes. [Continues.]
Funding
Lorenzayo Ltd. (Lagos, Nigeria).
History
School
- Science
Department
- Chemistry
Publisher
© Adelaide Titilayo Oluronke Morenike AdebayoPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/Publication date
1988Notes
A doctoral thesis submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en