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Synthetic and antimicrobial studies of nitroimidazole analogues

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thesis
posted on 2018-02-26, 14:34 authored by Adelaide T.O.M. Adebayo
New 2-, 4- and 5-nitroimidazole analogues were synthesised using the following methods: (i) SRN1 free radical reaction between nitroimidazole anion and halonitro substrates; (ii) oxidative addition of the anion of 2-nitropropane to nitroimidazole anions. N-1-alkyl derivatives of imidazole, benzimidazole, 5-nitrobenzimidazole, 5- and 6-nitroindazole were similarly prepared. These compounds showed antimicrobial activity; anaerobes were more sensitive than aerobes. [Continues.]

Funding

Lorenzayo Ltd. (Lagos, Nigeria).

History

School

  • Science

Department

  • Chemistry

Publisher

© Adelaide Titilayo Oluronke Morenike Adebayo

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/

Publication date

1988

Notes

A doctoral thesis submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

  • en

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