Thesis-1990-Lawrence.pdf (4.63 MB)
Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites
thesis
posted on 2018-05-14, 11:00 authored by Andrew J. LawrenceThe thesis is presented in two parts, part one concerns the synthesis and biodistribution of technetium–porphyrin
complexes. A series of compounds with the general formula TcO(Porhyrin)OAc and
TcO(Phthalocyanine)OPh have been synthesised via a novel route. The starting material comprised
NH4TcO4 with acetic acid for the porphyrin and phenol for the phthalocyanine. The compounds have been
characterised both qualitatively and quantitatively by infra-red, ultra-violet and mass spectrometry. Thin
Layer Chromatography (TLC) and electrophoresis have also been employed to further analyse the complexes.
Preliminary biodistribution studies have been performed in a model of inflamed tissue. The results suggest
that the labelled porphyrins are capable of imaging such tissue. One of the complexes was tested for an ability
to accumulate in, and image tumours, however this proved unsuccessful. [Continues.]
History
School
- Science
Department
- Chemistry
Publisher
© Andrew John LawrencePublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
1990Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en