Bishop_8261432.pdf (1.84 MB)
Regulation of metabolic disease-associated inflammation by nutrient sensors
journal contribution
posted on 2018-07-03, 08:52 authored by Alex S. Yamashita, Thiago Belchior, Fabio S. Lira, Nicolette BishopNicolette Bishop, Barbara Wessner, Jose C. Rosa, William T. FestucciaVisceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β31
cell dysfunction. Herein we review the mechanisms by which nutrients modulate obesity associated inflammation.
Funding
Funding was provided by Sao Paulo Research Foundation (FAPESP) to ASY (#13/15825-5), TB (#15/22983-1) and to WTF (#10/52191-6 and 15/19530-5).
History
School
- Sport, Exercise and Health Sciences
Published in
Mediators of InflammationCitation
YAMASHITA, A.S. ... et al, 2018. Regulation of metabolic disease-associated inflammation by nutrient sensors. Mediators of Inflammation, 2018: 8261432.Publisher
Hindawi Publishing Corporation © The AuthorsVersion
- NA (Not Applicable or Unknown)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2018-06-14Publication date
2018Notes
This is an Open Access Article. It is published by the Hindawi Publishing Corporation under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/. This is the accepted version of the article. It will be replaced by the published version once this is available.ISSN
0962-9351eISSN
1466-1861Publisher version
Language
- en