Thesis-2005-Tandy.pdf (7.27 MB)
New routes to highly functionalised heterocyclic compounds from cyclopropanes
thesis
posted on 2018-07-13, 10:39 authored by Matthew D. TandyHeterocyclic compounds are of great importance in the pharmaceutical
industry as well as academic research so key methodology, which generates a highly
functionalized medium ring in the minimum number of steps, is of great interest.
This project addresses this challenge by looking at the formation of pyrrolidines and
furans from cyclopropanes via a [2+3] cycloaddition reaction in a highly atom
efficient approach.
Prior to our work in this field, Tsuji and others have shown the formation of
a zwitterionic π-allyl palladium complex derived from vinylcyclopropanes and
naphthalenes is possible. During the project, we have improved the understanding of
the formation of zwitterionic π-allyl palladium complexes in aromatic systems. [Continues.]
Funding
EPSRC. Roche AG.
History
School
- Science
Department
- Chemistry
Publisher
© Matt TandyPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2005Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en