Abu_Bakar_Nagy_ Reilly_2008.pdf (291.65 kB)
Towards the development of a polymorphic control approach in sulfathiazole crystalization
conference contribution
posted on 2009-06-01, 11:40 authored by Mohd R. Abu Bakar, Zoltan NagyZoltan Nagy, Chris RiellyChris RiellyControlling the formation of a specific polymorphic form of active pharmaceutical ingredients,
particularly those that exhibit multiple polymorphic forms, during crystallization is critical for
pharmaceutical manufacturers. This paper describes the construction of a phase diagram using
Lasentec Focused Beam Reflectance Measurement (FBRM), which is an important step in the
development of an approach for polymorphic control of sulfathiazole, an antimicrobial agent that
is known to crystallize as a mixture of polymorphs. A preliminary work on mapping of different
regions in the phase diagram, where various polymorphic forms were found, is also reported
here. This study is part of a larger study on polymorphic control of pharmaceuticals through
supersaturation control using Process Analytical Technology.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Citation
ABU BAKAR, M.R., NAGY, Z.K. and RIELLY, C.D., 2008. Towards the development of a polymorphic control approach in sulfathiazole crystalization. IN: Lorenz, H. and Kaemmerer, H. (eds.). BIWIC 2008 / 15th International Workshop on Industrial Crystallization, September 10-12, 2008, Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg, Germany. Aachen : Shaker Publishing, pp. 235-242Publisher
© Shaker PublishingVersion
- AM (Accepted Manuscript)
Publication date
2008Notes
This conference paper was published in BIWIC 2008 [© Shaker Publishing] which is available from: http://www.shaker.eu/ISBN
9783832275051Language
- en