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Towards the development of a polymorphic control approach in sulfathiazole crystalization

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conference contribution
posted on 2009-06-01, 11:40 authored by Mohd R. Abu Bakar, Zoltan NagyZoltan Nagy, Chris RiellyChris Rielly
Controlling the formation of a specific polymorphic form of active pharmaceutical ingredients, particularly those that exhibit multiple polymorphic forms, during crystallization is critical for pharmaceutical manufacturers. This paper describes the construction of a phase diagram using Lasentec Focused Beam Reflectance Measurement (FBRM), which is an important step in the development of an approach for polymorphic control of sulfathiazole, an antimicrobial agent that is known to crystallize as a mixture of polymorphs. A preliminary work on mapping of different regions in the phase diagram, where various polymorphic forms were found, is also reported here. This study is part of a larger study on polymorphic control of pharmaceuticals through supersaturation control using Process Analytical Technology.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

ABU BAKAR, M.R., NAGY, Z.K. and RIELLY, C.D., 2008. Towards the development of a polymorphic control approach in sulfathiazole crystalization. IN: Lorenz, H. and Kaemmerer, H. (eds.). BIWIC 2008 / 15th International Workshop on Industrial Crystallization, September 10-12, 2008, Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg, Germany. Aachen : Shaker Publishing, pp. 235-242

Publisher

© Shaker Publishing

Version

  • AM (Accepted Manuscript)

Publication date

2008

Notes

This conference paper was published in BIWIC 2008 [© Shaker Publishing] which is available from: http://www.shaker.eu/

ISBN

9783832275051

Language

  • en

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