Electrospun Polycaprolactone Nano-fibers Supports Growth of Human Mesenchymal Stem Cells_Andrea Fotticchia.pdf (499.34 kB)
Electrospun polycaprolactone nano-fibers supports growth of human mesenchymal stem cells
conference contribution
posted on 2014-01-24, 10:10 authored by Andrea Fotticchia, Yang LiuYang Liu, Emrah DemirciEmrah Demirci, Cristina LenardiElectrospun polycaprolactone (PCL) layers with sub-micron fibres arranged in random, semi-aligned and aligned manners were prepared and their anisotropic mechanical property were further characterised at various stretching angle. Proof of principle study was carried out to assess biocompatibility of electrospun layers with human mesenchymal stem cells (hMSCs). Cell adhesion, viability and orientation outcomes showed that aligned PCL nano-fibers can be applied as a template to guide the alignment of hMSCs and could be a promising scaffold for tissue engineering of anisotropic annulus fibrosus in spinal inter-vertebral disc.
Funding
Research supported by Loughborough University graduate school PhD studentship (AF) and Royal Society.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Citation
FOTTICCHIA, A. ... et al., 2013. Electrospun polycaprolactone nano-fibers supports growth of human mesenchymal stem cells. IN: Proceedings of the 13th IEEE International Conference on Nanotechnology, Beijing, China, 5-8 August 2013, 4pp, doi: 10.1109/NANO.2013.6720851Publisher
© IEEEVersion
- AM (Accepted Manuscript)
Publication date
2013Notes
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Language
- en