Svendsen et al 2014 ISRN Nutrition.pdf (1.62 MB)
Influence of hydration status on changes in plasma cortisol, leukocytes and antigen-stimulated cytokine production by whole blood culture following prolonged exercise.
journal contribution
posted on 2014-03-19, 13:20 authored by Ida S. Svendsen, Sophie C. Killer, Michael GleesonElevated antigen-stimulated anti-inflammatory cytokine production appears to be a risk factor for upper respiratory tract illness
in athletes. The purpose of this study was to determine the effects of prolonged exercise and hydration on antigen-stimulated
cytokine production. Twelve healthy males cycled for 120min at 60% 𝑉O2 max on two occasions, either euhydrated or moderately
hypohydrated (induced by fluid restriction for 24 h). Blood samples were collected before and after exercise and following 2 h
recovery for determination of cell counts, plasma cortisol, and in vitro antigen-stimulated cytokine production by whole blood
culture. Fluid restriction resulted in mean body mass loss of 1.3% and 3.9% before and after exercise, respectively. Exercise elicited
a significant leukocytosis and elevated plasma cortisol, with no differences between trials. IL-6 production was significantly
reduced 2 h postexercise (𝑃 < 0.05), while IL-10 production was elevated postexercise (𝑃 < 0.05). IFN-𝛾 and IL-2 production
tended to decrease postexercise. No significant effect of hydration status was observed for the measured variables. Prolonged
exercise appears to result in augmented anti-inflammatory cytokine release in response to antigen challenge, possibly coupled with
acute suppression of proinflammatory cytokine production, corresponding with studies using mitogen or endotoxin as stimulant.
Moderate hypohydration does not appear to influence these changes.
History
School
- Sport, Exercise and Health Sciences
Citation
SVENDSEN, I.S., KILLER, S.C. and GLEESON, M., 2014. Influence of hydration status on changes in plasma cortisol, leukocytes and antigen-stimulated cytokine production by whole blood culture following prolonged exercise. ISRN Nutrition, 2014, Article ID 561401Publisher
Hindawi Publishing Corporation / © The authorsVersion
- VoR (Version of Record)
Publication date
2014Notes
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ISSN
2314-4068Publisher version
Language
- en