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Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity
journal contribution
posted on 2014-07-23, 11:18 authored by Malachy McCann, Robert Curran, Marcia Ben-Shoshan, Vickie McKee, Asif A. Tahir, Michael Devereux, Kevin Kavanagh, Bernadette S. Creaven, Andrew Kellett[Ag2(9-aca)2] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give
[Ag(imidH)2.3(CH3CN)0.7](9-aca) (3), [Ag6(imidH)4(9-aca)6(MeOH)2] (4), {[Ag(1-Me-imid)2]2[Ag4(9-
aca)6]} (5), {[Ag(1-Bu-imid)2]2[Ag4(9-aca)6]} (6) and [Ag(apim)](9-aca)·H2O (7) (imidH = imidazole;
1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole).
The mononuclear complex 3, hexanuclear 4–6, and polymeric 7, were all characterised using X-ray
crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial
activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can
survive high doses of the Ag(I) complexes administered in vivo, and a number of the complexes offer
significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells.
Funding
Financial support from the Irish Research Council for Science, Engineering and Technology (IRCSET) and the John and Pat Hume Scholarship Scheme, NUI Maynooth (R. Curran) are gratefully acknowledged.
History
School
- Science
Department
- Chemistry
Published in
DALTON TRANSACTIONSVolume
41Issue
21Pages
6516 - 6527 (12)Citation
McCANN, M. ... et al, 2012. Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity. Dalton Transactions, 41(21), pp.6516-6527.Publisher
© The Royal Society of ChemistryVersion
- NA (Not Applicable or Unknown)
Publication date
2012Notes
This item is Closed Access.ISSN
1477-9226Publisher version
Language
- en