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Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes
journal contribution
posted on 2015-09-15, 13:44 authored by Kathryn L. Gempf, Stephen ButlerStephen Butler, Alexander M. Funk, David ParkerA cysteine-selective tagging method in water is reported, based on rapid displacement of a pyridyl nitro-substituent in simple pyridines and lanthanide complexes. The conjugation reaction creates a short link between the tag and peptide, holding the peptide closer to the Ln3+ ion and with reduced flexibility compared to existing methods.
Funding
We thank the ERC for support (FCC 266804).
History
School
- Science
Department
- Chemistry
Published in
CHEMICAL COMMUNICATIONSVolume
49Issue
80Pages
9104 - 9106 (3)Citation
GEMPF, K.L. ... et al, 2013. Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes. Chemical Communications, 49 (80), pp. 9104 - 9106.Publisher
© The Royal Society of ChemistryVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2013Notes
This article is closed access.ISSN
1359-7345Publisher version
Language
- en