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Physical activity, sedentary time, and pericardial fat in healthy older adults
journal contribution
posted on 2015-10-30, 15:43 authored by Mark Hamer, Shreenidhi M. Venuraju, Livia Urbanova, Avijit Lahiri, Andrew SteptoePericardial fat is emerging as a unique risk factor for coronary disease. We examined the relationship between objectively measured physical activity during free-living and pericardial fat. Participants were 446 healthy men and women (mean age = 66 ± 6 years), without history or objective signs of cardiovascular disease (CVD), drawn from the Whitehall II epidemiological cohort. Physical activity was objectively measured using accelerometers (Actigraph GT3X)
worn around the hip during waking hours for 7 consecutive days (average daily wear time = 889 ± 68 min/day), and was classified as sedentary (<200 counts/min (cpm)), light (200–1,998 cpm), or moderate-vigorous physical activity (MVPA; ≥1,999 cpm). Pericardial fat volume was measured in each participant using electron beam computed tomography. Average daily cpm in men was 338.0 ± 145.0 and in women 303.8 ± 130.2. There was an inverse association between
average cpm and pericardial fat (B = –0.070, 95% confidence interval (CI), –0.101, –0.040, P < 0.001), and this remained
significant after adjusting for age, sex, registered wear time, BMI, lipids, glycemic control, blood pressure, smoking, statins, and social status. Both sedentary time (B = 0.081, 95% CI, 0.022, 0.14) and MVPA (B = –0.362, 95% CI, –0.527, –0.197) were also associated with pericardial fat, although associations for sedentary time did not remain significant after adjustment for MVPA. The inverse association between physical activity and pericardial fat was stronger among overweight and obese adults than in normal weight. Objectively assessed daily activity levels are related to pericardial fat in healthy participants, independently of BMI. This might be an important mechanism in explaining the association between physical activity and CVD prevention.
Funding
This research was supported by the British Heart Foundation and the BUPA Foundation, UK.
History
School
- Sport, Exercise and Health Sciences
Published in
ObesityCitation
HAMER, M. ...et al., 2012. Physical activity, sedentary time, and pericardial fat in healthy older adults. Obesity, 20(10), pp. 2113–2117.Publisher
© The Obesity SocietyVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2012Notes
This paper is in closed access.ISSN
1071-7323Publisher version
Language
- en