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The association between cortisol response to mental stress and high-sensitivity cardiac troponin T plasma concentration in healthy adults
journal contribution
posted on 2015-11-02, 11:33 authored by Antonio I. Lazzarino, Mark Hamer, David Gaze, Paul Collinson, Andrew SteptoeObjectives The objective of this study was to examine the association between cortisol response to mental stress and highsensitivity
cardiac troponin T (hs-cTnT) in healthy older individuals without history of cardiovascular disease (CVD).
Background Mental stress is a recognized risk factor for CVD, although the mechanisms remain unclear. Cortisol, a key stress
hormone, is associated with coronary atherosclerosis and may accentuate structural and functional cardiac disease.
Methods This cross-sectional study involved 508 disease-free men and women aged 53 to 76 years drawn from the Whitehall II epidemiological cohort. We evaluated salivary cortisol response to standardized mental stress tests (exposure) and
hs-cTnT plasma concentration using a high-sensitivity assay (outcome). We measured coronary calcification using
electron-beam dual-source computed tomography and Agatston scores.
Results After adjustment for demographic and clinical variables associated withCVDaswell as for inflammatory factors,wefound
a robust association between cortisol response and detectable hs-cTnT (odds ratio [OR]: 3.98; 95% confidence interval
[CI]: 1.60 to 9.92; p¼ 0.003). The association remained when we restricted the analysis to participants without coronary
calcification (n¼222; OR: 4.77; 95%CI: 1.22 to 18.72; p¼0.025) or when we further adjusted for coronary calcification
in participants with positive Agatston scores (n ¼ 286; OR: 7.39; 95% CI: 2.22 to 26.24; p ¼ 0.001).
Conclusions We found that heightened cortisol response to mental stress was associated with detectable plasma levels of cTnT using high-sensitivity assays in healthy participants, independently of coronary atherosclerosis. Further research is
needed to understand the role of psychosocial stress in the pathophysiology of cardiac cell damage.
History
School
- Sport, Exercise and Health Sciences
Published in
Journal of the American College of CardiologyCitation
LAZZARINO, A.I. ... et al., 2013. The association between cortisol response to mental stress and high-sensitivity cardiac troponin T plasma concentration in healthy adults. Journal of the American College of Cardiology, 62(18), pp. 1694–1701.Publisher
© ElsevierVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2013Notes
This paper is in closed access.ISSN
1558-3597Publisher version
Language
- en