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A new simplified protocol for copper(I) alkyne–azide cycloaddition reactions using low substoichiometric amounts of copper(II) precatalysts in methanol
journal contribution
posted on 2016-05-26, 11:46 authored by Benjamin BuckleyBenjamin Buckley, Maria M.P. Figueres, Amna N. Khan, Harry HeaneyCopper(II) carboxylates are reduced efficiently by methanol in the presence of alkynes and form yellow alkynylcopper(I) polymeric precatalysts that are involved with azides, in the absence of added ligands, in the catalytic cycles that result in the formation of 1,4-disubstituted 1,2,3-triazoles.
Funding
The authors are grateful to The Higher Education Commission of Pakistan for a visiting fellowship (to A.N.K.) and the EU Lifelong Learning Programme for support (to M.M.P.F), and Loughborough University for research funding. B.R.B. also thanks Research Councils UK for a RCUK fellowship.
History
School
- Science
Department
- Chemistry
Published in
SYNLETTVolume
27Issue
1Pages
51 - 56 (6)Citation
BUCKLEY, B. ... et al., 2016. A new simplified protocol for copper(I) alkyne–azide cycloaddition reactions using low substoichiometric amounts of copper(II) precatalysts in methanol. SYNLETT, DOI: 10.1055/s-0035-1560526.Publisher
© Georg ThiemeVersion
- AM (Accepted Manuscript)
Publisher statement
This paper was accepted for publication in the journal SYNLETT and the definitive published version is available at https://doi.org/10.1055/s-0035-1560526Publication date
2016-01-31ISSN
0936-5214eISSN
1437-2096Publisher version
Language
- en