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Fumarate-loaded electrospun nanofibers with anti-inflammatory activity for fast recovery of mild skin burns
journal contribution
posted on 2016-11-17, 11:27 authored by Ilaria Romano, Maria Summa, Jose A. Heredia-Guerrero, R. Spano, Luca Ceseracciu, C. Pignatelli, Rosalia Bertorelli, Elisa MeleElisa Mele, Athanassia AthanassiouIn the biomedical sector the availability of engineered scaffolds and dressings that control and reduce inflammatory states is highly desired, particularly for the management of burn wounds. In this work, we demonstrate for the first time, to the best of our knowledge, that electrospun fibrous dressings of poly(octyl cyanoacrylate) (POCA) combined with polypropylene fumarate (PPF) possess anti-inflammatory activity and promote the fast and effective healing of mild skin burns in an animal model. The fibers produced had an average diameter of (0.8 ± 0.1) µm and they were able to provide a conformal coverage of the injured tissue. The application of the fibrous mats on the burned tissue effectively reduced around 80% of the levels of pro-inflammatory cytokines in the first 48 h in comparison with un-treated animals, and enhanced skin epithelialization. From histological analysis, the skin thickness of the animals treated with POCA : PPF dressings appeared similar to that of one of the naïve animals: (13.7 ± 1.4) µm and (14.3 ± 2.5) µm for naïve and treated animals, respectively. The density of dermal cells was comparable as well: (1100 ± 112) cells mm−2 and (1358 ± 255) cells mm−2 for naïve and treated mice, respectively. The results demonstrate the suitability of the electrospun dressings in accelerating and effectively promoting the burn healing process.
Funding
José A Heredia-Guerrero is supported by a Marie Curie In-tra-European Fellowship (BIOPROTO project), financed by the EU's Seventh Framework Programme for Research (FP7).
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Materials
Published in
Biomedical MaterialsVolume
11Issue
4Pages
041001 - 041001Citation
ROMANO, I. ... et al, 2016. Fumarate-loaded electrospun nanofibers with anti-inflammatory activity for fast recovery of mild skin burns. Biomedical Materials, 11 (4), pp. 041001-041001.Publisher
© IOP PublishingVersion
- AM (Accepted Manuscript)
Acceptance date
2016-06-16Publication date
2016Notes
This is an author-created, un-copyedited version of an article published in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://dx.doi.org/10.1088/1748-6041/11/4/041001ISSN
1748-6041eISSN
1748-605XPublisher version
Language
- en