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The effect of active pharmaceutical ingredients on aerosol electrostatic charges from pressurized metered dose inhalers
journal contribution
posted on 2017-06-09, 13:38 authored by Yang Chen, Paul M. Young, David F. Fletcher, Hak Kim Chan, Edward LongEdward Long, David Lewis, Tanya Church, Daniela TrainiPurpose.
This study investigated the effect of different active pharmaceutical ingredients (API) on aerosol electrostatic charges and aerosol performances for pressurized metered dose inhalers (pMDIs), using both insulating and conducting actuators.
Methods.
Five solution-based pMDIs containing different API ingredients including: beclomethasone dipropionate (BDP), budesonide (BUD), flunisolide (FS), salbutamol base (SB) and ipratropium bromide (IPBr) were prepared using pressure filling technique. Actuator blocks made from nylon, polytetrafluoroethylene (PTFE) and aluminium were manufactured with 0.3 mm nominal orifice diameter and cone nozzle shape. Aerosol electrostatics for each pMDI formulation and actuator were evaluated using the electrical low-pressure impactor (ELPI) and drug depositions were analysed using high performance liquid chromatography (HPLC).
Results.
All three actuator materials showed the same net charge trend across the five active drug ingredients, with BDP, BUD and FS showing positive net charges for both nylon and PTFE actuators, respectively. While SB and IPBr had significantly negative net charges across the three different actuators, which correlates to the ionic functional groups present on the drug molecule structures.
Conclusions.
The API present in a pMDI has a dominant effect on the electrostatic properties of the formulation, overcoming the charge effect arising from the actuator materials. Results have shown that the electrostatic charges for a solution-based pMDI could be related to the interactions of the chemical ingredients and change in the work function for the overall formulation.
Funding
This research was supported under Australian Research Council’s Linkage Projects funding scheme (project number ARCLP100200156) and Chiesi Ltd, Chippenham, Wiltshire, United Kingdom. Professor Traini is the recipient of an Australian Research Council Future Fellowship (project number FT12010063). Professor Young is the recipient of an Australian Research Council Future Fellowship (project number FT110100996).
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Pharmaceutical ResearchCitation
CHEN, Y. ... et al., 2015. The effect of active pharmaceutical ingredients on aerosol electrostatic charges from pressurized metered dose inhalers. Pharmaceutical Research, 32(9), pp.2928-2936.Publisher
© SpringerVersion
- SMUR (Submitted Manuscript Under Review)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2015Notes
The final publication is available at Springer via: http://dx.doi.org/10.1007/s11095-015-1674-6.ISSN
0724-8741eISSN
1573-904XPublisher version
Language
- en