mASTANA_n3_fatty_acids_and_asthma.pdf (844.04 kB)
N-3 fatty acids and asthma
journal contribution
posted on 2017-07-03, 10:27 authored by Aishwarya Kumar, Sarabjit MastanaSarabjit Mastana, Martin LindleyCopyright © 2016 The Authors. Asthma is one of the most common and prevalent problems worldwide affecting over 300 million individuals. There is some evidence from observational and intervention studies to suggest a beneficial effect of n-3 PUFA in inflammatory diseases, specifically asthma. Marine-based n-3 PUFA have therefore been proposed as a possible complementary/alternative therapy for asthma. The proposed anti-inflammatory effects of n-3 fatty acids may be linked to a change in cell membrane composition. This altered membrane composition following n-3 fatty acid supplementation (primarily EPA and DHA) can modify lipid mediator generation via the production of eicosanoids with a reduced inflammatory potential/impact. A recently identified group of lipid mediators derived from EPA including E-series resolvins are proposed to be important in the resolution of inflammation. Reduced inflammation attenuates the severity of asthma including symptoms (dyspnoea) and exerts a bronchodilatory effect. There have been no major health side effects reported with the dietary supplementation of n-3 fatty acids or their mediators; consequently supplementing with n-3 fatty acids is an attractive non-pharmacological intervention which may benefit asthma.
History
School
- Sport, Exercise and Health Sciences
Published in
Nutrition Research ReviewsVolume
29Issue
1Pages
1 - 16Citation
KUMAR, A., MASTANA, S.S. and LINDLEY, M.R., 2016. N-3 Fatty acids and asthma. Nutrition Research Reviews, 29(1), pp. 1-16.Publisher
© The Authors. Published by Cambridge University Press.Version
- VoR (Version of Record)
Publication date
2016-01-26Notes
This article has been published in a revised form in Nutrition Research Reviews http://dx.doi.org/10.1017/S0954422415000116. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.ISSN
0954-4224eISSN
1475-2700Publisher version
Language
- en