Saradabani_Driven-Translocation-Semiflexible_Sci.Reps.7.(2017).7423.pdf (3.05 MB)
Driven translocation of a semi-flexible polymer through a nanopore
journal contribution
posted on 2017-09-05, 10:27 authored by Jalal Sarabadani, Timo Ikonen, Harri Mokkonen, Tapio Ala-NissilaTapio Ala-Nissila, Spencer Carson, Meni Wanunu© 2017 The Author(s). We study the driven translocation of a semi-flexible polymer through a nanopore by means of a modified version of the iso-flux tension propagation theory, and extensive molecular dynamics (MD) simulations. We show that in contrast to fully flexible chains, for semi-flexible polymers with a finite persistence length l p the trans side friction must be explicitly taken into account to properly describe the translocation process. In addition, the scaling of the end-to-end distance R N as a function of the chain length N must be known. To this end, we first derive a semi-analytic scaling form for R N , which reproduces the limits of a rod, an ideal chain, and an excluded volume chain in the appropriate limits. We then quantitatively characterize the nature of the trans side friction based on MD simulations. Augmented with these two factors, the theory shows that there are three main regimes for the scaling of the average translocation time τ ∞N α . In the rod l p1, Gaussian l p 1 0 2 and excluded volume chain N / κ p 10 6 limits, α = 2, 3/2 and 1 + ν, respectively, where ν is the Flory exponent. Our results are in good agreement with available simulations and experimental data.
History
School
- Science
Department
- Mathematical Sciences
Published in
Scientific ReportsVolume
7Issue
1Citation
SARABADANI, J. ...et al., 2017. Driven translocation of a semi-flexible polymer through a nanopore. Scientific Reports, 7:7423.Publisher
© the Authors. Published by the Nature Publishing GroupVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2017-06-26Publication date
2017Notes
This is an Open Access Article. It is published by Nature Publishing Group under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/eISSN
2045-2322Publisher version
Language
- en