Thesis-1999-Mansfield.pdf (3.15 MB)
The synthesis of novel agents which inhibit tumour-stimulated bone resorption
thesis
posted on 2017-11-14, 17:22 authored by Ian D. MansfieldA range of conjugates which focused on bisphosphonates as delivery
molecules and on oestrogens as resorption inhibitors were synthesised.
Various moieties were coupled through an ester linkage to bisphosphonates
which were then converted to the corresponding bisphosphonic acids. This
ester linkage was considered to be readily hydrolysable under normal
physiological conditions. [Continues.]
History
School
- Science
Department
- Chemistry
Publisher
© Ian MansfieldPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/Publication date
1999Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en