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First asymmetric synthesis of the natural enantiomer of the indolizidino[8,7-b]indole alkaloid harmicine
journal contribution
posted on 2007-06-26, 13:32 authored by Steven Allin, Sean N. Gaskell, Mark ElsegoodMark Elsegood, William P. MartinWe report a novel, facile and asymmetric approach for the synthesis of the indole alkaloid harmicine via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step, and verify the relative stereochemistry of the key synthetic intermediate in this approach through X-ray crystallography.
History
School
- Science
Department
- Chemistry
Citation
ALLIN, S.M ... et al, 2007. A new asymmetric synthesis of the natural enantiomer of the indolizidino[8,7-b]indole alkaloid (+)-harmicine. Tetrahedron letters, 48 (32), 6 August, pp. 5669-5671Publisher
© ElsevierPublication date
2007Notes
This article was published in the journal, Tetrahedron letters [© Elsevier]. The definitive version is available at: http://www.sciencedirect.com/science/journal/00404039.ISSN
0040-4039Language
- en