Thesis-2018-Gabbott.pdf (15.91 MB)
Investigation of cell–cell and cell–scaffold interactions through 2-D cell culture, 3-D tissue models and a simulated host system
thesis
posted on 2020-12-07, 16:46 authored by Christopher GabbottFrom the onset, the discipline of tissue engineering stated the promise of providing engineered tissues or organs for clinical applications. Nevertheless, this has remained an arduous task, due to the inadequate mechanistic understanding of the rudimentary cell-cell and cell-scaffold interactions that occur during tissue regeneration. Consequently, in this thesis, a simulated host environment was established, so that the costly and controversial in-vivo models could be superseded by in-vitro techniques, which can rapidly acquire insight of the aforementioned issues. However, due to the deficient knowledge in the field, the development of the simulated host system was hindered by several inaccurate conclusions which were fundamental prior to this thesis. [Continues.]
Funding
EPSRC
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Publisher
Loughborough UniversityRights holder
© Christopher Michael GabbottPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2018Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.Language
- en
Supervisor(s)
Tao SunQualification name
- PhD
Qualification level
- Doctoral