Swarbrick2019_Article_SystematicReviewOfMiRNAAsBioma.pdf (3.58 MB)
Systematic review of miRNA as biomarkers in Alzheimer’s disease
journal contribution
posted on 2019-03-06, 13:32 authored by Samantha Swarbrick, Nick Wragg, Sourav GhoshSourav Ghosh, Alexandra StolzingAlexandra StolzingCurrently there are 850,000 people with Alzheimer’s disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer’s disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a progressive decline in cognitive impairment. Small non-coding microRNA (miRNA) sequences have been found to be deregulated in the peripheral blood of Alzheimer patients. A systematic review was conducted to extract all miRNA found to be significantly deregulated in the peripheral blood. These deregulated miRNAs were cross-referenced against the miRNAs deregulated in the brain at Braak Stage III. This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer’s disease, nearly 20 years before the onset of clinical symptoms. After network analysis of the 10 miRNAs, they were found to be associated with the immune system, cell cycle, gene expression, cellular response to stress, neuron growth factor signalling, wnt signalling, cellular senescence, and Rho GTPases.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Molecular NeurobiologyVolume
56Issue
9Pages
6156 - 6167Citation
SWARBRICK, S. ... et al, 2019. Systematic review of miRNA as biomarkers in Alzheimer’s disease. Molecular Neurobiology, 56 (9), pp.6156–6167.Publisher
Springer © The Author(s)Version
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Acceptance date
2019-01-18Publication date
2019Notes
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.ISSN
0893-7648eISSN
1559-1182Publisher version
Language
- en