Thesis-2011-Towler.pdf (6.1 MB)
The application of intramolecular n-acyliminium cyclisation strategies towards biologically active heterocycles
thesis
posted on 2011-11-22, 14:21 authored by Joannah M.R. TowlerWe describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[2,1-a]benzazepine template which is a sub-unit of the Homoerythrina alkaloids, and the functionalised dodecahydrobenz[a]indolo[3,2-h]quinolizine template, which is a sub-unit of the manadomanzamine alkaloids. In addition, we have described an asymmetric synthesis of the α-hydrazino pyrroloisoquinoline ring system, towards the synthesis of conformationally restricted peptidomimetics.
History
School
- Architecture, Building and Civil Engineering
Research Unit
- Centre for Innovative and Collaborative Engineering (CICE)
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© Joannah M.R. TowlerPublication date
2011Notes
A dissertation thesis submitted in partial fulfilment of the requirements for the award of the Engineering Doctorate (EngD) degree, at Loughborough University.ISBN
9781907382543Language
- en
Qualification name
- EngD
Qualification level
- Doctoral
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