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Mass transfer resistance in a liquid-phase microextraction employing a single hollow fibre under nonsteady-state conditions
journal contribution
posted on 2012-07-25, 09:03 authored by Ksenija R. Kumric, Goran T. Vladisavljevic, Jelena S. Dordevic, Jan Ake Jonsson, Tatjana M. Trtic-PetrovicIn this study, the mass transport resistance in liquid-phase microextraction in a single hollow
fibre (HF-LPME) was investigated. A mathematical model has been developed for the
determination of the overall mass transfer coefficient based on the acceptor phase, KA, in an
unsteady-state HF-LPME. KA in HF-LPME has been estimated from time-dependent
concentration of extracted analyte in the acceptor phase while maintaining a constant analyte
concentration in the donor phase. It can be achieved either using a high volume of donor to
acceptor phase ratio or tuning the extraction conditions to obtain a low enrichment factor, so
that the analyte concentration in the sample is not significantly influenced by the mass
transfer. Two HF-LPME systems have been used to test experimentally the developed model:
the extraction of Lu(III) from a buffer solution and the extraction of three local anaesthetics
from a buffer or plasma solution. The mass transfer resistance, RA, defined as a reciprocal
values of KA, was found to be 1.2103 cm-1 min for Lu(III) in HF-LPME under optimal
conditions. The RA values for the local anaesthetics were in the range from 1.96 to 3.3 103
cm-1 min, depending on the acceptor pH and the hydrophobicity of the drug.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Citation
KUMRIC, K.R. ... et al., 2012. Mass transfer resistance in a liquid-phase microextraction employing a single hollow fibre under nonsteady-state conditions. Journal of Separation Science, 35 (18), pp.2390–2398.Publisher
© WileyVersion
- AM (Accepted Manuscript)
Publication date
2012Notes
Closed access. This paper is in press and was accepted for publication in the Journal of Separation Science [© Wiley]. The publisher's website is at: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1615-9314/ISSN
1615-9306eISSN
1615-9314Language
- en