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Title: Influence of training load on upper respiratory tract infection incidence and antigen-stimulated cytokine production
Authors: Gleeson, Michael
Bishop, Nicolette
Oliveira, Marta
Tauler, Pedro
Keywords: Exercise
Immunity
Leukocytes
Illness
Interleukins
Issue Date: 2013
Publisher: © John Wiley and Sons
Citation: GLEESON, M. ... et al., 2013. Influence of training load on upper respiratory tract infection incidence and antigen-stimulated cytokine production. Scandinavian Journal of Medicine and Science in Sports, 23 (4), pp. 451–457.
Abstract: This study examined the effect of training load on upper respiratory tract infection (URTI) incidence in men and women engaged in endurance-based physical activity during winter and sought to establish if there are training-associated differences in immune function related to patterns of illness. Seventy-five individuals provided resting blood and saliva samples for determination of markers of systemic immunity. Weekly training and illness logs were kept for the following 4 months. Comparisons were made between subjects (n = 25) who reported that they exercised 3–6 h/week (LOW), 7–10 h/week (MED) or ≥ 11 h/week (HIGH). The HIGH and MED groups had more URTI episodes than the LOW group (2.4 ± 2.8 and 2.6 ± 2.2 vs 1.0 ± 1.6, respectively: P < 0.05). The HIGH group had approximately threefold higher interleukin (IL)-2, IL-4 and IL-10 production (all P < 0.05) by antigen-stimulated whole blood culture than the LOW group and the MED group had twofold higher IL-10 production than the LOW group (P < 0.05). Other immune variables were not influenced by training load. It is concluded that high levels of physical activity are associated with increased risk of URTI and this may be related to an elevated anti-inflammatory cytokine response to antigen challenge.
Description: This article was published in the journal, Scandinavian Journal of Medicine and Science in Sports [© John Wiley and Sons] and the definitive version is available at: http://dx.doi.org/10.1111/j.1600-0838.2011.01422.x
Sponsor: Funded by Yakult Honsha Co., Ltd, Japan GlaxoSmithKline, UK Spanish Ministry of Science and Education
Version: Accepted for publication
DOI: 10.1111/j.1600-0838.2011.01422.x
URI: https://dspace.lboro.ac.uk/2134/10574
Publisher Link: http://dx.doi.org/10.1111/j.1600-0838.2011.01422.x
ISSN: 0905-7188
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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