ROWE, W., PLATT, M. and DAY, P.J.R., 2009. Advances and perspectives in aptamer arrays. Integrative Biology, 1 (1), pp.53-58.
Aptamers are oligonucleotides (typically 10–60 bases in length) capable of binding target ligands
with affinities similar to antibodies. The generation of high density multiplexed aptamer arrays for
molecular diagnostics was first proposed nearly ten years ago for the quantification of the
thousands of proteins within biological samples, including blood and urine. The tagless aptameric
detection of small molecular compounds extends the application of such arrays to bioanalyses at
the metabolite level. We present here a minireview on some existing technologies and highlight
recent innovations that are being applied to this field, which may facilitate the vision of highly
multi-parallelized arrays for the quantitative analysis of biological systems.