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Title: Effect of exercise and heat-induced hypohydration on brain volume
Authors: Watson, Phillip
Head, Kay
Pitiot, Alain
Morris, Peter
Maughan, Ronald J.
Keywords: Dehydration
Cerebrospinal fluid
Issue Date: 2010
Publisher: Lippincott, Williams & Wilkins (© American College of Sports Medicine)
Citation: WATSON, P. ... et al, 2010. Effect of exercise and heat-induced hypohydration on brain volume. Medicine and Science in Sports and Exercise, 42 (12), pp.2197-2204.
Abstract: Purpose: The aim of the present study was to quantify changes in brain volume following exercise/heat-induced hypohydration in man. Methods: Eight active men completed intermittent exercise in a warm environment, until 2.9 ± 0.1 % of body mass was lost. Subjects remained hypohydrated for two hours following the end of exercise. Brain volume was measured before, immediately following, and 1h and 2h after exercise using MRI (Philips 3T Achieva). Measures of subjective feelings and core body temperature were also monitored. Blood samples were drawn to determine serum electrolyte concentrations and osmolality and to allow calculation of changes in blood and plasma volumes. Results: Brain volume was not influenced by hypohydration (0.2 ± 0.4 %; ES 0.2; P = 0.310). Reductions in ventricular (4.0 ± 1.8 %; ES 4.6; P < 0.001) and CSF (3.1 ± 1.9%; ES 3.3; P = 0.003) volumes were observed following exercise. Compared with pre-exercise levels, serum osmolality was elevated throughout the 2h post-exercise period (+10 ± 2 mosmol/kg; P < 0.001). Core temperature increased from 37.1 ± 0.3oC at rest to 39.3 ± 0.5oC at the end of exercise (P = 0.001). Conclusions: These data demonstrate that brain volume remains unchanged in response to moderate hypohydration and the presence of serum hyperosmolality, suggesting that mechanisms are in place to defend brain volume.
Description: This is a non-final version of an article published in final form in the journal, Medicine and Science in Sports and Exercise: http://journals.lww.com/acsm-msse/
Version: Accepted for publication
DOI: 10.1249/MSS.0b013e3181e39788
URI: https://dspace.lboro.ac.uk/2134/11373
Publisher Link: http://dx.doi.org/10.1249/MSS.0b013e3181e39788
ISSN: 0195-9131
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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