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Title: Optimal seed recipe design for crystal size distribution control for batch cooling crystallisation processes
Authors: Aamir, Erum
Nagy, Zoltan K.
Rielly, Chris D.
Keywords: Seed design
Population balance modelling
Crystallisation control
Crystallisation
Optimisation
Product design
Quality-by-design
Issue Date: 2010
Publisher: © Elsevier
Citation: AAMIR, E., NAGY, Z.K. and RIELLY, C.D., 2010. Optimal seed recipe design for crystal size distribution control for batch cooling crystallisation processes. Chemical Engineering Science, 65 (11), pp.3602-3614.
Abstract: The paper presents a novel quality-by-design framework for the design of optimal seed recipes for batch cooling crystallisation systems with the aim to produce a desired target crystal size distribution (CSD) of the product. The approach is based on a population balance model-based optimal control framework, which optimizes the compositions of seed blends, based on seed fractions that result from standard sieve analysis. The population balance model is solved using a combined quadrature method of moments and method of characteristics (QMOM-MOCH) approach for the generic case of apparent size-dependent growth. Seed mixtures are represented as a sum of Gaussian distributions, where each Gaussian corresponds to the seed distribution in a particular sieve size range. The proposed methods are exemplified for the model system of potassium dichromate in water, for which the apparent size-dependent growth kinetic parameters have been identified from laboratory experiments. The paper also illustrates the simultaneous application of in situ process analytical tools, such as focused beam reflectance measurement (FBRM) for nucleation detection, attenuated total reflection (ATR) UV/Vis spectroscopy for concentration monitoring, as well as the in-line use of laser diffraction particle sizing for real-time CSD measurement.
Description: This is the author’s version of a work that was accepted for publication in the Chemical Engineering Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published at: http://dx.doi.org/10.1016/j.ces.2010.02.051
Version: Accepted for publication
DOI: 10.1016/j.ces.2010.02.051
URI: https://dspace.lboro.ac.uk/2134/11456
Publisher Link: http://dx.doi.org/10.1016/j.ces.2010.02.051
ISSN: 0009-2509
Appears in Collections:Published Articles (Chemical Engineering)

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