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Title: The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells
Authors: Handzlik, Michal K.
Shaw, Andrew J.
Dungey, Maurice
Bishop, Nicolette
Gleeson, Michael
Issue Date: 2013
Citation: HANDZLIK, M.K. ... et al, 2013. The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells. European Journal of Applied Physiology, February 2013, pp.1-10.
Abstract: Highly trained athletes are associated with high resting antigen-stimulated whole blood culture interleukin (IL)-10 production. The purpose of the present study was to examine the effects of training status on resting circulating T regulatory (T) cell counts and antigen-stimulated IL-10 production and the effect of acute bout of exercise on the T response. Forty participants volunteered to participate and were assigned to one of the four groups: sedentary (SED), recreationally active (REC), sprint-trained athletes and endurance-trained athletes (END). From the resting blood sample, CD4CD25CD127 T cells and in vitro antigen-stimulated IL-10 production were assessed. Ten REC subjects performed 60 min cycling at 70 % of maximal oxygen uptake and blood samples for T analysis were collected post- and 1 h post-exercise. IL-10 production was greater in END compared with the other groups (P < 0.05). END had a higher T percentage of total lymphocyte count compared with SED (P < 0.05). A smaller proportion of T CD4 cells were observed in SED compared with all other groups (P < 0.05). IL-10 production significantly correlated with the proportion of T within the total lymphocyte population (r = 0.51, P = 0.001). No effect of acute exercise was evident for T cell counts in the REC subjects (P > 0.05). Our results demonstrate that high training loads in END are associated with greater resting IL-10 production and T cell count and suggest a possible mechanism for depression of immunity commonly reported in athletes engaged in high training loads. © 2013 Springer-Verlag Berlin Heidelberg.
Description: The final publication is available at springerlink.com.
Version: Accepted for publication
DOI: 10.1007/s00421-013-2614-y
URI: https://dspace.lboro.ac.uk/2134/11860
Publisher Link: http://dx.doi.org/10.1007/s00421-013-2614-y
ISSN: 1439-6319
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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