BUCKLEY, B.R., PATEL, A.P. and WIJAYANTHA, K.G.U., 2013. Observations on the modified Wenker synthesis of aziridines and the development of a biphasic system. Journal of Organic Chemistry, 78 (3), pp.1289-1292.
A cheap and reliable process for the modified Wenker cyclization to afford
aziridines has been achieved using biphasic conditions for a range of amino alcohol
starting materials. A 100 mmol “one-pot” process has also been devised and
enantiopurity of the starting amino alcohol is retained in the aziridine product.