In our studies towards the synthesis of tetronothiodin, we completed the synthesis
of 195, a precursor of the oxaspirobyciclic unit of tetronothiodin.
The synthesis was achieved in an eight step strategy and afforded the α-hydroxy
lactone 195 as a diasteroisomeric mixture with 194 in a 5.7% overall yield.....
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.