Pyrrolisoquinoline (B) is found as a major structural motif of the erythrina alkaloid
group of natural products. We recognised that a suitably substituted bicyclic lactam
(A) could act as a precursor in an intramolecular N-acyliminium mediated
cyclisation reaction in a stereoselective approach to the core of the erythrinane target
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.