Thesis-2009-McCauley.pdf (3.48 MB)
Are ACE I/D and ACTN3 R577X polymorphisms associated with muscle function of young and older men, and frequent fallers?
thesis
posted on 2013-08-09, 15:09 authored by Tracey McCauleyAngiotensin Converting Enzyme (ACE) IID, and a actinin 3 (AC1N3) R577X
polymorphisms have been linked to the strength and power performance of elite athletes and
suggested to influence skeletal muscle function in the general popUlation. This research
investigated the association of these two candidate gene polymorphisms with the muscle
function of young and older men, and the distribution of these genotypes in frequent fallers
compared to controls. Muscle function measurements of young and older men included
isometric strength, absolute and relative isokinetic strength at high velocity (ratio of torque
at 2400 ·s"; torque at 30°·s") and the time course of an evoked twitch. Additionally body
composition was measured by skinfold thickness (young men) and DXA scanning (old men)
to estimate fat-free mass, an index of muscularity, and fat mass. ACE and AC1N3
genotypes were determined from whole blood samples using polymerase chain reaction, and
serum ACE activity using spectrophotometry. The gemtypes of frequent fallers referred to a
Falls Clinic were compared to a control group of healthy men. ACE genotype was not
associated with any measure of muscle function, including the time course of an evoked
twitch or absolute and relative high velocity torque, or body composition in these
populations (ANOVA, 0.12
History
School
- Sport, Exercise and Health Sciences
Publisher
© Tracey McCauleyPublication date
2009Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough UniversityEThOS Persistent ID
uk.bl.ethos.516273Language
- en