+44 (0)1509 263171
Please use this identifier to cite or link to this item:
|Title: ||Progress towards the design and numerical analysis of a 3D microchannel biochip separator|
|Authors: ||Xue, Xiangdong|
Patel, Mayur K.
Kay, Robert W.
Desmulliez, Marc P.Y.
|Issue Date: ||2011|
|Publisher: ||© John Wiley & Sons Ltd.|
|Citation: ||XUE, X. ... et al, 2011. Progress towards the design and numerical analysis of a 3D microchannel biochip separator. International Journal for Numerical Methods in Biomedical Engineering, 27 (11), pp.1771–1792.|
|Abstract: ||This paper reports the design and numerical analysis of a three-dimensional biochip plasma blood
separator using Computational Fluid Dynamics (CFD) techniques. Based on the initial
configuration of a 2D separator, five 3D microchannel biochip designs are categorically developed
through axial and plenary symmetrical expansions. These include the geometric variations of three
types of the branch side channels (circular, rectangular, disc) and two types of the main channel
(solid and concentric). Ignoring the initial transient behaviour and assuming that steady state flow
has been established, the behaviour of the blood fluid in the devices is algebraically analysed and
numerically modelled. The roles of the relevant microchannel mechanisms, i.e. bifurcation,
constriction and bending channel, on promoting the separation process are analysed based on
modelling results. The differences among the different 3D implementations are compared and
discussed. The advantages of 3D over 2D separator in increasing separation volume and effectively
depleting cell-free layer fluid from the whole cross section circumference are addressed and
|Description: ||This is the pre-peer reviewed version of the article which has been published in final form at: http://dx.doi.org/10.1002/cnm.1439|
|Version: ||Submitted for publication|
|Publisher Link: ||http://dx.doi.org/10.1002/cnm.1439|
|Appears in Collections:||Published Articles (Mechanical, Electrical and Manufacturing Engineering)|
Files associated with this item:
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.