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Vladisavljevic et all - Scale up strategies for industrial lab on a chip application.pdf (4.84 MB)

Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery

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journal contribution
posted on 2013-11-18, 13:11 authored by Goran VladisavljevicGoran Vladisavljevic, Nauman Khalid, Marcus A. Neves, Takashi Kuroiwa, Mitsutoshi Nakajima, Kunihiko Uemura, Sosaku Ichikawa, Isao Kobayashi
Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery. © 2013 Elsevier B.V. All rights reserved.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

VLADISAVLJEVIC, G.T. ... et al, 2013. Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery. Advanced Drug Delivery Reviews, 65 (11-13), pp. 1626–1663

Publisher

© Elsevier B.V.

Version

  • AM (Accepted Manuscript)

Publication date

2013

Notes

This article was published in the journal, Advanced Drug Delivery Reviews [© Elsevier B.V.]. The definitive version is available at: http://dx.doi.org/10.1016/j.addr.2013.07.017

ISSN

0169-409X

eISSN

1872-8294

Language

  • en