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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/13579

Title: Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery
Authors: Vladisavljevic, Goran T.
Khalid, Nauman
Neves, Marcus A.
Kuroiwa, Takashi
Nakajima, Mitsutoshi
Uemura, Kunihiko
Ichikawa, Sosaku
Kobayashi, Isao
Keywords: Microfluidics
Device fabrication
Unit operation
Monodisperse droplets
Parallel flow
Functional materials
Biological processing
Issue Date: 2013
Publisher: © Elsevier B.V.
Citation: VLADISAVLJEVIC, G.T. ... et al, 2013. Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery. Advanced Drug Delivery Reviews, 65 (11-13), pp. 1626–1663
Abstract: Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery. © 2013 Elsevier B.V. All rights reserved.
Description: This article was published in the journal, Advanced Drug Delivery Reviews [© Elsevier B.V.]. The definitive version is available at: http://dx.doi.org/10.1016/j.addr.2013.07.017
Version: Accepted for publication
DOI: 10.1016/j.addr.2013.07.017
URI: https://dspace.lboro.ac.uk/2134/13579
Publisher Link: http://dx.doi.org/10.1016/j.addr.2013.07.017
ISSN: 0169-409X
Appears in Collections:Published Articles (Chemical Engineering)

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