Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/13582

Title: A rapid and highly diastereoselective synthesis of enantiomerically pure (4R,5R)- and (4S,5S)-isocytoxazone
Authors: Buckley, Benjamin R.
Page, Philip C. Bulman
McKee, Vickie
Keywords: Diastereoselective
Cytoxazone
Tyrosine
Oxazolidinone
Oxidation
Issue Date: 2011
Publisher: © Georg Thieme Verlag Stuttgart
Citation: BUCKLEY, B.R., PAGE, P.C.B. and MCKEE, V., 2011. A rapid and highly diastereoselective synthesis of enantiomerically pure (4R,5R)- and (4S,5S)-isocytoxazone. Synlett, 10, pp. 1399 - 1402.
Abstract: A three-step protocol for the highly diastereoselective (>98%) synthesis of both (4R,5R)- and (4S,5S)-isocytoxazone from d- or l-tyrosine is reported. The diastereoselection was confirmed by X-ray crystallography. This synthesis is currently the highest yielding approach towards these enantiomerically pure biologically active oxazolidinones.
Description: This article was published in the journal Synlett [© Georg Thieme Verlag Stuttgart]. The definitive version is available at: http://dx.doi.org/10.1055/s-0030-1260561
Version: Accepted for publication
DOI: 10.1055/s-0030-1260561
URI: https://dspace.lboro.ac.uk/2134/13582
Publisher Link: http://dx.doi.org/10.1055/s-0030-1260561
ISSN: 0936-5214
Appears in Collections:Published Articles (Chemistry)

Files associated with this item:

File Description SizeFormat
BRBuckleyISOX.pdf441.6 kBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.