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Title: Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles: experiments and numerical simulations
Authors: Vladisavljevic, Goran T.
Shahmohamadi, Hamed
Das, Diganta Bhusan
Ekanem, Ekanem E.
Taunov, Zhandos
Sharma, Lav
Keywords: Drop microfluidics
Flow focusing
Poly(lactic acid)
Monodispersed microparticle
Ultrasound contrast agent
Computational Fluid Dynamics
Porous particle
Lidocaine hydrochloride
Controlled drug release
Issue Date: 2014
Publisher: Elsevier © the authors
Citation: VLADISAVLJEVIC, G.T. ... et al, 2014. Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles: experiments and numerical simulations. Journal of Colloid and Interface Science, 418, pp. 163-170.
Abstract: Hypothesis: Droplet size in microfluidic devices is affected by wettability of the microfluidic channels. Three-dimensional countercurrent flow focusing using assemblies of chemically inert glass capillaries is expected to minimize wetting of the channel walls by the organic solvent. Experiments: Monodispersed polycaprolactone and poly(lactic acid) particles with a diameter of 18-150 μm were produced by evaporation of solvent (dichloromethane or 1:2 mixture of chloroform and toluene) from oil-in-water or water-in-oil-in-water emulsions produced in three-dimensional flow focusing glass capillary devices. The drop generation behaviour was simulated numerically using the volume of fluid method. Findings: The numerical results showed good agreement with high-speed video recordings. Monodispersed droplets were produced in the dripping regime when the ratio of the continuous phase flow rate to dispersed phase flow rate was 5-20 and the Weber number of the dispersed phase was less than 0.01. The porosity of polycaprolactone particles increased from 8 to 62% when 30 wt% of the water phase was incorporated in the organic phase prior to emulsification. The inner water phase was loaded with 0.156 wt% lidocaine hydrochloride to achieve a sustained drug release. 26 % of lidocaine was released after 1 h and more than 93 % of the drug was released after 130 h.
Description: This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/
Sponsor: The work was supported by the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom (grant reference number: EP/HO29923/1)
Version: Published
DOI: 10.1016/j.jcis.2013.12.002
URI: https://dspace.lboro.ac.uk/2134/13792
Publisher Link: http://dx.doi.org/10.1016/j.jcis.2013.12.002
Appears in Collections:Published Articles (Chemical Engineering)

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