SMITH, R.W. ... et al, 2013. Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Analytical Methods, 5 (16), pp.3799-3802.
Thermal desorption has been combined with field asymmetric
waveform ion mobility spectrometry and mass spectrometry for the
rapid, direct analysis of isobaric potentially genotoxic impurities
(PGIs) in a surrogate active pharmaceutical ingredient. FAIMSselected
PGIs were detected with limits of quantification <0.2 ppm,
below the threshold of toxicological concern, with %RSD <8.4%, at
the 1 ppm level.