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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/13847

Title: Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry
Authors: Smith, Robert W.
Reynolds, James C.
Lee, Sze-Ling
Creaser, Colin S.
Issue Date: 2013
Publisher: © Royal Society of Chemistry
Citation: SMITH, R.W. ... et al, 2013. Direct analysis of potentially genotoxic impurities by thermal desorption-field asymmetric waveform ion mobility spectrometry-mass spectrometry. Analytical Methods, 5 (16), pp.3799-3802.
Abstract: Thermal desorption has been combined with field asymmetric waveform ion mobility spectrometry and mass spectrometry for the rapid, direct analysis of isobaric potentially genotoxic impurities (PGIs) in a surrogate active pharmaceutical ingredient. FAIMSselected PGIs were detected with limits of quantification <0.2 ppm, below the threshold of toxicological concern, with %RSD <8.4%, at the 1 ppm level.
Description: This article is closed access.
Version: Published
DOI: 10.1039/c3ay40676h
URI: https://dspace.lboro.ac.uk/2134/13847
Publisher Link: http://dx.doi.org/10.1039/c3ay40676h
ISSN: 1759-9660
1759-9679
Appears in Collections:Closed Access (Chemistry)

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