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|Title: ||Influence of vitamin D metabolites on plasma cytokine concentrations in endurance sport athletes and on multiantigen stimulated cytokine production by whole blood and peripheral blood mononuclear cell cultures.|
|Authors: ||He, Cheng-Shiun|
Fraser, William D.
|Issue Date: ||2014|
|Publisher: ||Hindawi Publishing Corporation / © Cheng-Shiun He et al.|
|Citation: ||HE, C-S., FRASER, W.D. and GLEESON, M., 2014. Influence of vitamin D metabolites on plasma cytokine concentrations in endurance sport athletes and on multiantigen stimulated cytokine production by whole blood and peripheral blood mononuclear cell cultures. ISRN Nutrition, 2014, Article ID 820524.|
|Abstract: ||Our aims were to determine the influence of plasma total 25-hydroxy vitamin D (25(OH)D) status on the plasma cytokine
concentrations in athletes and the in vitro effects of different doses of 1, 25 dihydroxyvitamin D3 (1, 25(OH)2D3) on multiantigen
stimulated cytokine production by whole blood and peripheral bloodmononuclear cell (PBMC) cultures. Methods. Plasma samples
from 43 athletes with high and low levels of 25(OH)D were assayed for the concentrations of cytokines.The whole blood samples
and PBMCs from healthy subjects were incubated in vitro with a multi-antigen vaccine and different doses of added 1, 25(OH)2D3.
The circulating cytokines and stimulated whole blood and PBMC culture production of cytokines were determined using a biochip
assay. Results.The circulating interleukin-(IL-)10 and interferon-(IFN-) 𝛾 concentrations were significantly higher in the vitamin
D sufficient athletes. Furthermore, the production of tumour necrosis factor-(TNF-) 𝛼, IL-6, IFN-𝛾, IL-2, and IL-10 by whole blood
culture was significantly inhibited by 1, 25(OH)2D3 concentrations of 1000 pmol/L or 10000 pmol/L. Conclusions.We found that the
influence of vitamin D on circulating cytokines might be different in athletes compared with nonathletes and cytokines production
by whole blood culture was not influenced by 1, 25(OH)2D3 in concentrations within the normal healthy range.|
|Description: ||This article was published in the journal ISRN Nutrition, it is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Publisher Link: ||http://dx.doi.org/10.1155/2014/820524|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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