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|Title: ||Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: insights from the STAND programme of research|
|Authors: ||Wilmot, E.G.|
Edwardson, Charlotte L.
Biddle, Stuart J.H.
Nimmo, Myra A.
Yates, Thomas E.
Davies, Melanie J.
|Issue Date: ||2013|
|Publisher: ||© The Authors. Diabetic Medicine © Diabetes UK|
|Citation: ||WILMOT, E.G. ... et al., 2013. Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: insights from the STAND programme of research. Diabetic Medicine, 30 (6), pp. 671 - 675.|
|Abstract: ||Aims. Rising rates of obesity have led to an increasing prevalence of Type 2 diabetes mellitus in young people.
Uncertainty exists over the utility of screening younger adults for Type 2 diabetes, as existing data sets have focused on
mature (> 40 years) cohorts. The aim of this study was to determine the prevalence of impaired glucose metabolism in
higher risk younger adults.
Methods. Overweight (with an additional risk factor) or obese adults (18–40 years) were recruited for the Sedentary
Time And Diabetes (STAND) randomized controlled trial. Measures included an oral glucose tolerance test, HbA1c,
biochemical and anthropometric data.
Results. One hundred and ninety-three individuals (68% female; median age 33.8 years; median BMI 33.9 kg/m2) were
recruited. Forty-three per cent had a first-degree family history of Type 2 diabetes. Previously undiagnosed Type 2
diabetes was present in 4.7% (n = 9). Of participants, 18.1% (n = 35) had impaired glucose metabolism: 4.7% (n = 9)
HbA1c 48 mmol/mol (6.5%); 9.3% (n = 18) HbA1c 42–46 mmol/mol (6.0–6.4%); 3.1% (n = 6) Type 2 diabetes on
oral glucose tolerance test; 6.2% (n = 12) isolated impaired glucose tolerance; 2.1% (n = 4) isolated impaired fasting
glucose; 1% (n = 2) both impaired fasting glucose and impaired glucose tolerance. Of participants, 58.5% (n = 113) had
dyslipidaemia, 28.0% (n = 54) had hypertension, 31.1% (n = 60) were vitamin D deficient and 7.3% (n = 14) had
abnormal liver function.
Conclusions. This study identified a high prevalence of Type 2 diabetes and impaired glucose regulation in overweight
and obese younger adults. These findings require confirmation in a larger, representative, population.|
|Description: ||This article was published in the journal, Diabetic Medicine [© The Authors. Diabetic Medicine © Diabetes UK] and the definitive version is available at: http://dx.doi.org/10.1111/dme.12173|
|Sponsor: ||The STAND study is a MRC (NPRI) funded study [grant number #91409].|
|Version: ||Submitted for publication|
|Publisher Link: ||http://dx.doi.org/10.1111/dme.12173|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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