PRIEST, J. ... et al, 2013. An asymmetric synthesis of trans-fused butyrolactones from endoperoxides. Journal of Organic Chemistry, 78 (7), pp. 3476 - 3481
The intermolecular addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities. This methodology expands the synthetic utility of endoperoxides and further underlines their potential as sources of oxygen functionality for natural and non-natural product target synthesis.